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Textbook of Immunology

  • Author(s): Arvind Kumar
  • Size: 180 mm x 240 mm
  • Pages: 314
  • Binding: Paperback
  • Language: English
  • ISBN: 9788179933800
  • Cover Price:

    Rs.595.00 / US $35.00

  • Special Price: Rs. 535.00 / US $32.00

Book Details

The book provides in-depth but concise coverage of all the major topics of immunology in simple and lucid manner. The text of the book is illustrated with simplified well-labelled diagrams and pictures to make the subject easily understandable and interesting to read for students. Extensive cross-referencing between chapters is used to reinforce and broaden the understanding of the core concepts of immunology. This book might be an ideal source of comprehensive, authoritative, and up-to-date information for those who work in the field of immunology.

Key Features

  • Comprehensive and up-to-date coverage of key concepts in immunology
  • Extensive coverage of the composition of the immune system, antigens and immunogens
  • Detailed explanation of antigen and antibody interaction and major histocompatibility complex
  • Description of cell mediated immunity and cytotoxicity
  • Clear and logical format with easy and accessible information

Target Audience

    Undergraduate and Post-graduate students of Immunology, Researchers and teachers of Immunobiology

Table of Contents

    1. BASICS OF IMMUNITY
    1.1 Introduction
    1.2 Mechanism of Immunity
    1.3 Specificity of Antibodies
    1.4 Components of the Immune System
    1.5 Processing and Presentation of Antigens
    1.6 Clonal Selection of B Cells
    1.7 Cooperation between Innate Immunity and Adaptive Immunity
    1.8 Difference between Innate and Adaptive Immune Systems
    1.9 Immunity Malfunction and Immunodeficiency
    At a Glance
    Questions
    Objective Questions

    2. COMPOSITION OF IMMUNE SYSTEM
    2.1 Introduction
    2.2 Cell Death: Necrosis and Programmed Cell Death
    2.3 Cells of the Immune System
    2.4 Adaptive Immune System Cells
    2.5 Classification of Cell Markers Based on Structure
    2.6 Primary Lymphoid Organs and Tissues
    2.7 Positive Selection and Negative Selection of T Cells
    2.8 Secondary Lymphoid Organs
    2.9 Networking of Immune System
    At a Glance
    Questions
    Objective Questions

    3. ANTIGENS AND IMMUNOGENS
    3.1 Introduction
    3.2 Immunogen Determining Factors
    3.3 Properties of Antigens
    3.4 Various Forms of Antigens
    3.5 Role of Biological System in Immunogenicity
    3.6 Antigenic Determinants (Epitopes) and Paratopes
    3.7 Properties of B-Cell Active Sites
    3.8 Nature of B-Cell Epitopes Protein
    3.9 Location of B-Cell Epitopes
    3.10 Immunodominant and Overlapping Epitopes
    3.11 T-Cell Epitopes Derived from Antigens
    3.12 Hapten–Carrier Conjugates Antigenicity
    3.13 Epitope Mapping
    3.14 Pattern Recognition Receptor Protein
    3.15 TLR-Related Proteins
    3.16 Important Findings
    At a Glance
    Questions
    Objective Questions

    4. ANTIGEN DETERMINANTS
    4.1 Antibodies
    4.2 Sites for the Formation of Antibodies
    4.3 Glycosylation
    4.4 Enzymatic and Chemical-Based Study of Antibody Structure
    4.5 Sequencing of Immunoglobulin
    4.6 Fine Structure of Immunoglobulin
    4.7 Domains of Immunoglobulin
    4.8 X-Ray Crystallography of Domains
    4.9 Variability of Cdrs
    4.10 Constant Regions Domain and their Functions
    4.11 Effector Functions of Antibody
    4.12 Different Classes of Antibodies based on Constant Region
    4.13 Epitopes of Immunoglobulins
    4.14 Receptors of B Cells
    4.15 Immunoglobulin Superfamily
    4.16 Monoclonal Antibody
    4.17 Diversity of Antibody
    4.18 Variable Region DNA Rearrangement
    At a Glance
    Questions
    Objective Questions

    5. ANTIGEN AND ANTIBODY INTERACTION
    5.1 Introduction
    5.2 Types of Bonds in Antigen–Antibody Interaction
    5.3 Cross-Reactivity of Antibodies
    5.4 Techniques Based on Antigen–Antibody Reactions
    At a Glance
    Questions
    Objective Questions

    6. MAJOR HISTOCOMPATIBILITY COMPLEX
    6.1 Introduction
    6.2 Discovery of MHC
    6.3 Classes of MHC Molecules
    6.4 Types of Mice Strain Based on MHC
    6.5 Inheritance of HLA Haplotypes in Humans
    6.6 Structure of Class I Molecules and Class II Molecules
    6.7 Linkage Disequilibrium
    6.8 Relevance of MHC Polymorphism
    6.9 MHC Molecule Distribution in Various Cell Types
    6.10 Immune Responsiveness to MHC
    6.11 Variability in Immune Responsiveness
    6.12 MHC Gene Regulation
    6.13 TCR–CD3 Complex
    At a Glance
    Questions
    Objective Questions

    7. COMPLEMENT SYSTEM
    7.1 Introduction
    7.2 Synthesis and Components of the Complement System
    7.3 Activation of Complement System
    7.4 Regulation of the Complement System
    7.5 Effects of Complement Activation on Biological System
    7.6 Protection of Microbes Against Complement-Mediated Damage
    7.7 Deficiencies of Components of the Complement System
    At a Glance
    Questions
    Objective Questions

    8. REGULATION OF ADAPTIVE IMMUNE RESPONSE
    8.1 Introduction to Generation and Maturation of B Cells
    8.2 Role of B-Cell Coreceptor
    8.3 Role of TH Cells in B-Cell Responses
    8.4 Cytokines and its Role in B Cell
    8.5 Negative Selection of Mature Self-Reactive B Cells in Periphery
    8.6 Primary and Secondary Humoral Responses of B Cells
    8.7 Original Antigenic Sin
    8.8 Role of T Cells in Humoral Responses
    8.9 Secondary Modification of B Cells at Germinal Centre
    8.10 B Cells Development Regulation
    8.11 T-Cell Regulation
    At a Glance
    Questions
    Objective Questions

    9. CELL-MEDIATED IMMUNITY AND CYTOTOXICITY
    9.1 Introduction
    9.2 Mechanisms of Cell Targeting and Lysis Mediated by Cytotoxic
    T Cells and NK Cells
    9.3 Antibody-Dependent Cell-Mediated Cytotoxicity
    9.4 Macrophage-Mediated Cytotoxicity
    At a Glance
    Questions
    Objective Questions

    10. ALLERGIC REACTIONS OR HYPERSENSITIVITY
    10.1 Introduction
    10.2 Classification Based on Gell and Coombs Reaction
    10.3 Antibody-Dependent Allergic Reactions
    10.4 Antibody-Independent or Cell-Mediated Hypersensitivity
    At a Glance
    Questions
    Objective Questions

    11. AUTOIMMUNITY
    11.1 Introduction to Autoimmune Diseases
    11.2 Organ-Specific Autoimmune Diseases
    11.3 Diseases due to Stimulated or Blocked Autoantibodies
    11.4 Diseases Mediated by Hyper-Active Lymphocyte Cells
    11.5 Role of CD4+ T Cell, MHC, and TCR in Autoimmunity
    11.6 Autoimmune Development Mechanism
    At a Glance
    Questions
    Objective Questions

    12. IMMUNITY TO INFECTIONS AND TUMOURS
    12.1 Introduction
    12.2 Controlling Viral Infection
    12.3 Viral Component Taking Part in Infection
    12.4 Bacterial Infection and Immune Response
    12.5 Protozoan Infections
    12.6 Cancer
    12.7 Development of Modern Vaccines: Difficulties and Future Prospect
    At a Glance
    Questions
    Objective Questions

    13. IMMUNOLOGY OF GRAFT REJECTION OR TRANSPLANT REJECTIONS
    13.1 Introduction to Transplantation
    13.2 Immunology of Graft Rejection
    13.3 Immunotherapy and Drugs for Graft Acceptance
    13.4 Induction of Alloantigen Tolerance
    At a Glance
    Questions
    Objective Questions

    14. CYTOKINES
    14.1 Introduction
    14.2 Cytokine Receptors
    14.3 Classification of Cytokines
    14.4 Balance of Immune Regulator Cytokines
    14.5 Role of Cytokines in the Regulation of B Cells
    14.6 Cytokines in the Development and Maintenance of Immunological Memory
    14.7 Use of Cytokines as Vaccines
    At a Glance
    Questions
    Objective Questions

Keywords

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